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    pak2a p21 protein (Cdc42/Rac)-activated kinase 2a [ Danio rerio (zebrafish) ]

    Gene ID: 266749, updated on 15-Dec-2024

    Summary

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    Official Symbol
    pak2aprovided by ZNC
    Official Full Name
    p21 protein (Cdc42/Rac)-activated kinase 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021011-2
    See related
    Ensembl:ENSDARG00000068177 AllianceGenome:ZFIN:ZDB-GENE-021011-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pak2; cb422; kinase; zgc:91798; wu:fb71h01; si:dz198m22.1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development. Predicted to be active in cytoplasm. Is expressed in several structures, including Kupffer's vesicle; axial mesoderm; axial vasculature; axis; and central nervous system. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pak2a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (36609099..36636869)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (36626447..36654414)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886155 Neighboring gene inhibitor of growth family, member 5b Neighboring gene kelch-like family member 6 Neighboring gene cyclin L1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability. Thirugnanam K, et al. Biochem Pharmacol, 2022 Aug. PMID 35700757, Free PMC Article
    2. Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects. Wang Y, et al. Adv Sci (Weinh), 2023 Feb. PMID 36504449, Free PMC Article
    3. Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke. Gore AV, et al. Dis Model Mech, 2008 Nov-Dec. PMID 19093037, Free PMC Article
    4. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Berghmans S, et al. Proc Natl Acad Sci U S A, 2005 Jan 11. PMID 15630097, Free PMC Article
    5. Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death. Jeon HY, et al. FEBS J, 2013 Mar. PMID 23351126

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EphrinB ligands B2a and B3b, the Ephb4a receptor and the Pak2a kinase are required for the development of pharyngeal pouches and the segmentation of the posterior facial skeleton.
      Title: Eph-Pak2a signaling regulates branching of the pharyngeal endoderm by inhibiting late-stage epithelial dynamics.
    2. Essential in vivo role for betaPix and Pak2a during embryonic development and a previously unrecognized pathway specifically involved in cerebrovascular stabilization. [BetaPix AND Pak2a]
      Title: A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish.
    3. Data provide evidence for a critical function of Pak2 in vascular integrity and demonstrate a severe disease phenotype resulting from loss of Pak2 function.
      Title: pak2a mutations cause cerebral hemorrhage in redhead zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 2a
    Names
    p21 (CDKN1A)-activated kinase 2
    p21 (CDKN1A)-activated kinase 2a
    p21-activated kinase 2
    redhead
    rhd
    NP_001002717.1
    XP_005171319.1
    XP_005171320.1
    XP_068078998.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002717.1 → NP_001002717.1  serine/threonine-protein kinase PAK 2a

      See identical proteins and their annotated locations for NP_001002717.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076511
      UniProtKB/TrEMBL
      A0A0R4IQG0, A0A8N7XJE5, B2GRT8, Q6DG42
      Related
      ENSDARP00000089188.2, ENSDART00000098417.3
      Conserved Domains (3) summary
      cd06655
      Location:222 → 517
      STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
      smart00220
      Location:242 → 493
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:74 → 129
      PBD; P21-Rho-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      36609099..36636869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171263.5 → XP_005171320.1  serine/threonine-protein kinase PAK 2a isoform X1

      See identical proteins and their annotated locations for XP_005171320.1

      UniProtKB/TrEMBL
      A0A0R4IQG0, A0A8N7XJE5, B2GRT8, Q6DG42
      Conserved Domains (3) summary
      cd06655
      Location:222 → 517
      STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
      smart00220
      Location:242 → 493
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:74 → 129
      PBD; P21-Rho-binding domain

    2. XM_005171262.5 → XP_005171319.1  serine/threonine-protein kinase PAK 2a isoform X1

      See identical proteins and their annotated locations for XP_005171319.1

      UniProtKB/TrEMBL
      A0A0R4IQG0, A0A8N7XJE5, B2GRT8, Q6DG42
      Related
      ENSDARP00000137659.2, ENSDART00000159541.2
      Conserved Domains (3) summary
      cd06655
      Location:222 → 517
      STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
      smart00220
      Location:242 → 493
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:74 → 129
      PBD; P21-Rho-binding domain

    3. XM_068222897.1 → XP_068078998.1  serine/threonine-protein kinase PAK 2a isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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