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    ints9 integrator complex subunit 9 [ Danio rerio (zebrafish) ]

    Gene ID: 768124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ints9provided by ZNC
    Official Full Name
    integrator complex subunit 9provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-129
    See related
    Ensembl:ENSDARG00000067913 AllianceGenome:ZFIN:ZDB-GENE-061013-129
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7144223; zgc:154012
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to act upstream of or within snRNA processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to human INTS9 (integrator complex subunit 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ints9 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (49895220..49928452)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (50092006..50125238)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene homeobox containing 1 b Neighboring gene kinesin family member 13Bb Neighboring gene exostosin-like glycosyltransferase 3 Neighboring gene uncharacterized LOC101885653 Neighboring gene ribosomal oxygenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Biallelic sequence variants in INTS1 in patients with developmental delays, cataracts, and craniofacial anomalies. Krall M, et al. Eur J Hum Genet, 2019 Apr. PMID 30622326, Free PMC Article
    2. The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling. Tao S, et al. Development, 2009 Aug. PMID 19605500
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within snRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077270.1 → NP_001070738.1  integrator complex subunit 9

      See identical proteins and their annotated locations for NP_001070738.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124793
      UniProtKB/TrEMBL
      A0A8M1NA48, Q08BB6
      Related
      ENSDARP00000088637.3, ENSDART00000097865.5
      Conserved Domains (3) summary
      cd01392
      Location:532 → 573
      HTH_LacI; Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators
      smart01027
      Location:307 → 425
      Beta-Casp; Beta-Casp domain
      cd16294
      Location:1 → 265
      Int9-like_MBL-fold; integrator subunit 9, and related proteins; MBL-fold metallo-hydrolase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      49895220..49928452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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