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    pklr pyruvate kinase L/R [ Danio rerio (zebrafish) ]

    Gene ID: 114551, updated on 27-Dec-2024

    Summary

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    Official Symbol
    pklrprovided by ZNC
    Official Full Name
    pyruvate kinase L/Rprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010907-1
    See related
    Ensembl:ENSDARG00000042010 AllianceGenome:ZFIN:ZDB-GENE-010907-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fd15e01; wu:fi37e08
    Summary
    Predicted to enable pyruvate kinase activity. Acts upstream of or within liver development. Predicted to be active in cytoplasm. Is expressed in digestive system; female organism; heart; male organism; and muscle. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pklr in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54450407..54458866, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (54629441..54634683, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882272 Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Neighboring gene cytochrome P450, family 11, subfamily C, polypeptide 1 Neighboring gene CDC-like kinase 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Programming effects of high-carbohydrate feeding of larvae on adult glucose metabolism in zebrafish, Danio rerio. Fang L, et al. Br J Nutr, 2014 Mar 14. PMID 24112146
    2. Dose-dependent transcriptomic responses of zebrafish eleutheroembryos to Bisphenol A. Martínez R, et al. Environ Pollut, 2018 Dec. PMID 30248606
    3. Shared acquired genomic changes in zebrafish and human T-ALL. Rudner LA, et al. Oncogene, 2011 Oct 13. PMID 21552289, Free PMC Article
    4. Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. Li Z, et al. PLoS One, 2015. PMID 26147004, Free PMC Article
    5. Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Qi H, et al. Adv Sci (Weinh), 2021 Sep. PMID 34278746, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate kinase PKLR
    Names
    pyruvate kinase, liver and RBC
    NP_958446.1
    XP_021322272.1
    XP_068069969.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201289.1 → NP_958446.1  pyruvate kinase PKLR

      See identical proteins and their annotated locations for NP_958446.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055561
      UniProtKB/TrEMBL
      Q7SXK3
      Related
      ENSDARP00000069759.5, ENSDART00000075275.6
      Conserved Domains (2) summary
      cd00288
      Location:48 → 537
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:49 → 533
      pyruv_kin; pyruvate kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      54450407..54458866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466597.2 → XP_021322272.1  pyruvate kinase PKLR isoform X1

      UniProtKB/TrEMBL
      A0A8M9NZ14
      Conserved Domains (1) summary
      cd00288
      Location:37 → 526
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    2. XM_068213868.1 → XP_068069969.1  pyruvate kinase PKLR isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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