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    rad54b RAD54 homolog B [ Danio rerio (zebrafish) ]

    Gene ID: 560482, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rad54bprovided by ZNC
    Official Full Name
    RAD54 homolog Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-50
    See related
    Ensembl:ENSDARG00000092134 AllianceGenome:ZFIN:ZDB-GENE-060810-50
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7137737; im:7153525
    Summary
    Predicted to enable DNA translocase activity. Predicted to be involved in double-strand break repair via homologous recombination and reciprocal meiotic recombination. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Orthologous to human RAD54B (RAD54 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rad54b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (26732065..26757661)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (26858602..26884219)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene vir like m6A methyltransferase associated Neighboring gene ring finger protein 41, like Neighboring gene fibrinogen silencer binding protein Neighboring gene GTP binding protein overexpressed in skeletal muscle Neighboring gene cadherin 17, LI cadherin (liver-intestine)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cellular responses to ionizing radiation change quickly over time during early development in zebrafish. Honjo Y, et al. Cell Biol Int, 2019 May. PMID 30791195, Free PMC Article
    2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA translocase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair and recombination protein RAD54B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      26732065..26757661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_683887.10 → XP_688979.4  DNA repair and recombination protein RAD54B isoform X1

      UniProtKB/TrEMBL
      A0A8N7UUU9, E9QHY4
      Related
      ENSDARP00000113995.1, ENSDART00000138496.2
      Conserved Domains (3) summary
      cd00046
      Location:333 → 474
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:311 → 612
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:646 → 763
      Helicase_C; Helicase conserved C-terminal domain

    2. XM_068214142.1 → XP_068070243.1  DNA repair and recombination protein RAD54B isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials