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    afap1l1a actin filament associated protein 1-like 1a [ Danio rerio (zebrafish) ]

    Gene ID: 566757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    afap1l1aprovided by ZNC
    Official Full Name
    actin filament associated protein 1-like 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050913-76
    See related
    Ensembl:ENSDARG00000089162 AllianceGenome:ZFIN:ZDB-GENE-050913-76
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    afap1l1; zgc:114084
    Summary
    Predicted to be located in several cellular components, including actin cytoskeleton; anchoring junction; and cell projection. Predicted to be active in cytosol. Is expressed in hindbrain. Orthologous to human AFAP1L1 (actin filament associated protein 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See afap1l1a in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (34562426..34633960, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (34222112..34293646, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit pi Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene actin binding LIM protein family, member 3 Neighboring gene SH3 domain and tetratricopeptide repeats 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo. Meyen D, et al. Elife, 2015 Apr 15. PMID 25875301, Free PMC Article
    2. Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. Lagman D, et al. BMC Evol Biol, 2016 Jun 13. PMID 27296292, Free PMC Article
    3. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Choe SK, et al. Dev Biol, 2011 Oct 15. PMID 21787765, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114084

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin filament-associated protein 1-like 1
    Names
    AFAP1-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030213.1 → NP_001025384.1  actin filament-associated protein 1-like 1

      See identical proteins and their annotated locations for NP_001025384.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097145
      UniProtKB/Swiss-Prot
      Q4V8Y7
      Related
      ENSDARP00000111322.2, ENSDART00000128869.4
      Conserved Domains (3) summary
      cd13306
      Location:204 → 310
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:403 → 503
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:220 → 308
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      34562426..34633960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213234.1 → XP_068069335.1  actin filament-associated protein 1-like 1 isoform X3

      Related
      ENSDARP00000145106.1, ENSDART00000179977.1

    2. XM_009291126.4 → XP_009289401.1  actin filament-associated protein 1-like 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AS30
      Conserved Domains (3) summary
      cd13306
      Location:217 → 323
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:416 → 516
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:233 → 321
      PH; PH domain

    3. XM_005173256.5 → XP_005173313.1  actin filament-associated protein 1-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8RU06, A0A8M2BKK9
      Related
      ENSDARP00000152800.1, ENSDART00000191608.1
      Conserved Domains (3) summary
      cd13306
      Location:217 → 323
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:416 → 516
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:233 → 321
      PH; PH domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394919.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      65719..134781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395317.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      65713..136825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8Y7.1 GenPept UniProtKB/Swiss-Prot:Q4V8Y7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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