hsd11b1la hydroxysteroid (11-beta) dehydrogenase 1-like a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsd11b1laprovided by ZNC
Official Full Name: hydroxysteroid (11-beta) dehydrogenase 1-like aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1002
See related: Ensembl:ENSDARG00000071377 AllianceGenome:ZFIN:ZDB-GENE-040426-1002
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hsd3; 11-DH3; sdr10b; hsd11b3; hsd11b1l; hsd11b3a; zgc:56373; si:dkey-78l4.15
Summary: Predicted to enable steroid dehydrogenase activity. Predicted to be located in extracellular region. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in intestinal bulb. Orthologous to human HSD11B1L (hydroxysteroid 11-beta dehydrogenase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: chromosome: 22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (19553395..19562455)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (19528417..19537470)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables steroid dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hydroxysteroid 11-beta-dehydrogenase 1-like protein

Names: 11-beta-HSD3; 11-beta-hydroxysteroid dehydrogenase type 3; SDR family oxidoreductase; hydroxysteroid (11-beta) dehydrogenase 3; hydroxysteroid (11-beta) dehydrogenase 3a; short-chain dehydrogenase/reductase 10

NP_956617.2

EC 1.1.1.-

XP_068072363.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200323.2 → NP_956617.2 hydroxysteroid 11-beta-dehydrogenase 1-like protein precursor

See identical proteins and their annotated locations for NP_956617.2

Status: VALIDATED

Source sequence(s)

BC071452

UniProtKB/Swiss-Prot

Q6PUF3

Related

ENSDARP00000061738.3, ENSDART00000061739.4

Conserved Domains (2) summary

cd05332
Location:31 → 278

11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

pfam00106
Location:36 → 229

adh_short; short chain dehydrogenase