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    rab4a RAB4a, member RAS oncogene family [ Danio rerio (zebrafish) ]

    Gene ID: 403031, updated on 9-Dec-2024

    Summary

    Official Symbol
    rab4aprovided by ZNC
    Official Full Name
    RAB4a, member RAS oncogene familyprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040525-1
    See related
    Ensembl:ENSDARG00000019144 AllianceGenome:ZFIN:ZDB-GENE-040525-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc93b03; wu:fc93b03
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within vasculature development. Predicted to be located in early endosome membrane and recycling endosome membrane. Predicted to be active in insulin-responsive compartment and recycling endosome. Is expressed in retina. Orthologous to human RAB4A (RAB4A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See rab4a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (24295896..24311630, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (24165446..24181180, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene actin alpha 1, skeletal muscle b Neighboring gene centriole, cilia and spindle-associated protein b Neighboring gene si:ch211-202m22.1 Neighboring gene ras homolog family member Ua

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in insulin-responsive compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-4A
    NP_001119853.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126381.1NP_001119853.1  ras-related protein Rab-4A

      See identical proteins and their annotated locations for NP_001119853.1

      Status: VALIDATED

      Source sequence(s)
      BC056535, BC163906, CR762497, EH469961
      UniProtKB/Swiss-Prot
      Q6PHI9
      UniProtKB/TrEMBL
      B0V0U3
      Related
      ENSDARP00000012097.8, ENSDART00000004420.9
      Conserved Domains (2) summary
      smart00175
      Location:9172
      RAB; Rab subfamily of small GTPases
      cd04113
      Location:9169
      Rab4; Rab GTPase family 4 (Rab4)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      24295896..24311630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)