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    vwa1 von Willebrand factor A domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 568379, updated on 9-Dec-2024

    Summary

    Official Symbol
    vwa1provided by ZNC
    Official Full Name
    von Willebrand factor A domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5921
    See related
    Ensembl:ENSDARG00000075468 AllianceGenome:ZFIN:ZDB-GENE-030131-5921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi25e07; wu:fi25e07; si:dkey-3p8.6
    Summary
    Acts upstream of or within nervous system development; neural crest cell development; and regulation of cartilage development. Predicted to be located in basement membrane and extracellular region. Predicted to be active in collagen-containing extracellular matrix. Is expressed in head; pharyngeal arch; pharyngeal pouch; somite; and ventral mandibular arch. Used to study motor neuron disease. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 7. Orthologous to human VWA1 (von Willebrand factor A domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See vwa1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (39632660..39666525, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (39739749..39773704, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene G0/G1 switch 2 Neighboring gene OTU deubiquitinase 3 Neighboring gene transmembrane and coiled-coil domains 4 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 6 Neighboring gene mitochondrial contact site and cristae organizing system subunit 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General protein information

    Preferred Names
    von Willebrand factor A domain-containing protein 1
    Names
    transmembrane and coiled-coil domains 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423794.1NP_001410723.1  von Willebrand factor A domain-containing protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      BM104493, CA471904, CK027664, EB879387, EB919190, EE324972
      UniProtKB/Swiss-Prot
      E7FF10
      Related
      ENSDARP00000099327.3, ENSDART00000110868.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      39632660..39666525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005174134.5XP_005174191.1  von Willebrand factor A domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005174191.1

      UniProtKB/Swiss-Prot
      E7FF10
      Related
      ENSDARP00000157119.1, ENSDART00000190961.1
      Conserved Domains (2) summary
      cd01450
      Location:36195
      vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam00041
      Location:220307
      fn3; Fibronectin type III domain