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    pdpk1a 3-phosphoinositide dependent protein kinase 1a [ Danio rerio (zebrafish) ]

    Gene ID: 768202, updated on 15-Dec-2024

    Summary

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    Official Symbol
    pdpk1aprovided by ZNC
    Official Full Name
    3-phosphoinositide dependent protein kinase 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-109
    See related
    Ensembl:ENSDARG00000062304 AllianceGenome:ZFIN:ZDB-GENE-061013-109
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7158209; zgc:153787
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pdpk1a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (45285545..45308447, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (47333752..47346153, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 31 Neighboring gene potassium channel tetramerization domain containing 5a Neighboring gene interleukin 21 receptor, tandem duplicate 2 Neighboring gene uncharacterized LOC137490142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of the protein kinase inhibitor PKC412 on gene expression and link to physiological effects in zebrafish Danio rerio eleuthero-embryos. Oggier DM, et al. Toxicol Sci, 2011 Jan. PMID 20980353
    2. High-carbohydrate diet promotes the adaptation to acute hypoxia in zebrafish. Ma Q, et al. Fish Physiol Biochem, 2020 Apr. PMID 31820205
    3. Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Kahsay A, et al. Sci Rep, 2022 Oct 13. PMID 36229514, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-phosphoinositide-dependent protein kinase 1a
    NP_001070812.1
    XP_068073765.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077344.1 → NP_001070812.1  3-phosphoinositide-dependent protein kinase 1a precursor

      See identical proteins and their annotated locations for NP_001070812.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124736
      UniProtKB/TrEMBL
      Q08BG3
      Related
      ENSDARP00000093021.3, ENSDART00000102245.5
      Conserved Domains (3) summary
      smart00220
      Location:77 → 324
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:429 → 531
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:75 → 337
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      45285545..45308447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217664.1 → XP_068073765.1  3-phosphoinositide-dependent protein kinase 1a isoform X1

      Related
      ENSDARP00000129062.1, ENSDART00000155324.3
    Nucleotide Protein Strain
    Heading Accession and Version

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