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    rpl23a ribosomal protein L23a [ Danio rerio (zebrafish) ]

    Gene ID: 335539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rpl23aprovided by ZNC
    Official Full Name
    ribosomal protein L23aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7479
    See related
    Ensembl:ENSDARG00000006316 AllianceGenome:ZFIN:ZDB-GENE-030131-7479
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa93f05; wu:fj20e05; zgc:110139
    Summary
    Predicted to be a structural constituent of ribosome. Acts upstream of or within pancreas development and regulation of cell cycle. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in digestive system; endodermal cell; and epithelial cell of pancreas. Orthologous to human RPL23A (ribosomal protein L23a). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rpl23a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (26071900..26074640)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (26035205..26037945)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene SPT6 homolog, histone chaperone and transcription elongation factor Neighboring gene RAB34, member RAS oncogene family b Neighboring gene small nucleolar RNA Z17 Neighboring gene small nucleolar RNA SNORD42 Neighboring gene small nucleolar RNA SNORD42 Neighboring gene TLC domain containing 1 Neighboring gene NIPA like domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The tumor suppressor rpl36 restrains KRAS(G12V)-induced pancreatic cancer. Provost E, et al. Zebrafish, 2014 Dec. PMID 25380065, Free PMC Article
    2. Nuclear Organization during Hepatogenesis in Zebrafish Requires Uhrf1. Madakashira BP, et al. Genes (Basel), 2021 Jul 16. PMID 34356097, Free PMC Article
    3. Brain Proteome and Behavioural Analysis in Wild Type, BDNF(+/-) and BDNF(-/-) Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures. Maffioli E, et al. Int J Mol Sci, 2022 May 17. PMID 35628418, Free PMC Article
    4. Many ribosomal protein genes are cancer genes in zebrafish. Amsterdam A, et al. PLoS Biol, 2004 May. PMID 15138505, Free PMC Article
    5. Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Provost E, et al. Zebrafish, 2013 Jun. PMID 23697888, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110139

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001593.2 → NP_001001593.1  large ribosomal subunit protein uL23

      See identical proteins and their annotated locations for NP_001001593.1

      Status: PROVISIONAL

      Source sequence(s)
      AY561517
      UniProtKB/TrEMBL
      Q6Q416
      Related
      ENSDARP00000006624.5, ENSDART00000003001.8
      Conserved Domains (3) summary
      PTZ00191
      Location:35 → 155
      PTZ00191; 60S ribosomal protein L23a; Provisional
      PRK14548
      Location:73 → 155
      PRK14548; 50S ribosomal protein L23P; Provisional
      pfam03939
      Location:30 → 66
      Ribosomal_L23eN; Ribosomal protein L23, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      26071900..26074640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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