gins3 GINS complex subunit 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gins3provided by ZNC
Official Full Name: GINS complex subunit 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040721-1
See related: Ensembl:ENSDARG00000038847 AllianceGenome:ZFIN:ZDB-GENE-040721-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: flj13912; zgc:100834
Summary: Acts upstream of or within heart development. Predicted to be located in nucleus. Predicted to be part of GINS complex. Is expressed in alar plate midbrain region; nervous system; optic vesicle; pharyngeal arch; and presumptive neural retina. Orthologous to human GINS3 (GINS complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (13399967..13403655, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (13303567..13307255, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This sensitized zebrafish screen identified 15 novel myocardial repolarization genes. Among these genes is GINS3, the human ortholog of which is a major locus in 2 concurrent human genome-wide association studies of QT interval.
Title: Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GINS complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA replication complex GINS protein PSF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.