traip TRAF-interacting protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: traipprovided by ZNC
Official Full Name: TRAF-interacting proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-30
See related: Ensembl:ENSDARG00000011262 AllianceGenome:ZFIN:ZDB-GENE-040801-30
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TRIP; zgc:100878
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and replication fork processing. Predicted to be active in nucleus and site of DNA damage. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (35162825..35171161, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (34900842..34909178, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in site of DNA damage	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRAIP

NP_991170.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205607.1 → NP_991170.1 E3 ubiquitin-protein ligase TRAIP

See identical proteins and their annotated locations for NP_991170.1

Status: PROVISIONAL

Source sequence(s)

AY398425

UniProtKB/TrEMBL

Q6TGT1

Related

ENSDARP00000024931.7, ENSDART00000017393.9

Conserved Domains (2) summary

pfam13639
Location:7 → 50

zf-RING_2; Ring finger domain

cl09111
Location:136 → 256

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...