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    slc7a8a solute carrier family 7 member 8a [ Danio rerio (zebrafish) ]

    Gene ID: 100007704, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc7a8aprovided by ZNC
    Official Full Name
    solute carrier family 7 member 8aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-121120-2
    See related
    Ensembl:ENSDARG00000075831 AllianceGenome:ZFIN:ZDB-GENE-121120-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and neutral amino acid transport. Predicted to act upstream of or within amino acid transport and transmembrane transport. Predicted to be located in basolateral plasma membrane and lateral plasma membrane. Orthologous to human SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc7a8a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (24210086..24236282, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (23938929..23965125, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase 2 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Neighboring gene thioredoxin b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos. Stapel LC, et al. Development, 2016 Feb 1. PMID 26700682
    2. Leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1 activation are required for position-dependent regeneration. Takayama K, et al. Sci Rep, 2018 May 29. PMID 29844341, Free PMC Article
    3. Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. Walter KM, et al. PLoS One, 2019. PMID 31513589, Free PMC Article
    4. Effects of thyroid hormone disruption on the ontogenetic expression of thyroid hormone signaling genes in developing zebrafish (Danio rerio). Walter KM, et al. Gen Comp Endocrinol, 2019 Feb 1. PMID 30448381, Free PMC Article
    5. Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Szenker-Ravi E, et al. Nat Genet, 2022 Jan. PMID 34903892

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutral amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 7 member 8a
    Names
    solute carrier family 7 (amino acid transporter light chain, L system), member 8a
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 8a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271897.1 → NP_001258826.1  solute carrier family 7 member 8a

      Status: VALIDATED

      Source sequence(s)
      CR318603
      UniProtKB/TrEMBL
      A0A8M1P532, E7EXU6
      Related
      ENSDARP00000012295.8, ENSDART00000010124.10
      Conserved Domains (1) summary
      TIGR00911
      Location:1 → 497
      2A0308; L-type amino acid transporter

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      24210086..24236282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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