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    elac1 elaC ribonuclease Z 1 [ Danio rerio (zebrafish) ]

    Gene ID: 445109, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elac1provided by ZNC
    Official Full Name
    elaC ribonuclease Z 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-246
    See related
    Ensembl:ENSDARG00000045095 AllianceGenome:ZFIN:ZDB-GENE-040801-246
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91956
    Summary
    Predicted to enable 3'-tRNA processing endoribonuclease activity. Predicted to act upstream of or within tRNA processing. Predicted to be active in nucleus. Orthologous to human ELAC1 (elaC ribonuclease Z 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See elac1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (6854526..6864127)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (6291980..6301560)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene amphiregulin Neighboring gene malic enzyme 2, NAD(+)-dependent, mitochondrial Neighboring gene SMAD family member 4b Neighboring gene mex-3 RNA binding family member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution and Expression of Paxillin Genes in Teleost Fish. Jacob AE, et al. PLoS One, 2016. PMID 27806088, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3'-tRNA processing endoribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity, producing 5'-phosphomonoesters IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc phosphodiesterase ELAC protein 1
    Names
    elaC homolog 1
    NP_001003503.1
    XP_021331758.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003503.1 → NP_001003503.1  zinc phosphodiesterase ELAC protein 1

      See identical proteins and their annotated locations for NP_001003503.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078352
      UniProtKB/TrEMBL
      Q6DBV0
      Related
      ENSDARP00000066306.4, ENSDART00000066307.6
      Conserved Domains (2) summary
      COG1234
      Location:3 → 364
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      TIGR02651
      Location:4 → 364
      RNase_Z; ribonuclease Z

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      6854526..6864127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476083.2 → XP_021331758.1  zinc phosphodiesterase ELAC protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PXC3
      Conserved Domains (1) summary
      TIGR02651
      Location:4 → 395
      RNase_Z; ribonuclease Z

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394563.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      203622..213202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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