prkar2aa protein kinase, cAMP-dependent, regulatory, type II, alpha A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prkar2aaprovided by ZNC
Official Full Name: protein kinase, cAMP-dependent, regulatory, type II, alpha Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1007
See related: Ensembl:ENSDARG00000033184 AllianceGenome:ZFIN:ZDB-GENE-030131-1007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb55f12; wu:fj29e12; wu:fj33e06; zgc:153742
Summary: Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within phosphorylation and regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (26330277..26369116)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (26311138..26349977)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb18a07.y1 (e-PCR)
- UniSTS:190223

fb55f12.x1 (e-PCR)
- UniSTS:190741

fj29e12.x1 (e-PCR)
- UniSTS:198990

fl05f06.x1 (e-PCR)
- UniSTS:201902

fj33e06.x1 (e-PCR)
- UniSTS:199115

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein kinase, cAMP-dependent, regulatory, type II, alpha A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077370.2 → NP_001070838.2 protein kinase, cAMP-dependent, regulatory, type II, alpha A

Status: VALIDATED

Source sequence(s)

BC124725, BQ481277, CR847503, EB795367

UniProtKB/TrEMBL

A0A8M1NA89, A9C3T0, Q08BH1

Related

ENSDARP00000048675.7, ENSDART00000048676.9

Conserved Domains (3) summary

cd12103
Location:3 → 43

DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase

COG0664
Location:252 → 367

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:258 → 378

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...