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    ppp2r2bb protein phosphatase 2, regulatory subunit B, beta b [ Danio rerio (zebrafish) ]

    Gene ID: 558810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp2r2bbprovided by ZNC
    Official Full Name
    protein phosphatase 2, regulatory subunit B, beta bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-39
    See related
    Ensembl:ENSDARG00000099221 AllianceGenome:ZFIN:ZDB-GENE-041010-39
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ppp2r2b; zgc:101861
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be located in cytoskeleton and membrane. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppp2r2bb in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (41649506..41778818)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (41636126..41768030)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene prenylcysteine oxidase-like Neighboring gene prenylcysteine oxidase-like Neighboring gene microRNA 146b-1 Neighboring gene transcription elongation regulator 1b (CA150) Neighboring gene chaperonin containing TCP1, subunit 6A (zeta 1)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia. Spreafico M, et al. Front Cell Dev Biol, 2020. PMID 33015043, Free PMC Article
    2. Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. Lagman D, et al. BMC Evol Biol, 2016 Jun 13. PMID 27296292, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 2, regulatory subunit B, beta b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030122.3 → NP_001025293.2  protein phosphatase 2, regulatory subunit B, beta b

      Status: VALIDATED

      Source sequence(s)
      BX005397, CU929230
      UniProtKB/TrEMBL
      A0A0R4IEA6, A0A8M1N7E1
      Related
      ENSDARP00000131058.1, ENSDART00000169511.2
      Conserved Domains (3) summary
      COG5170
      Location:17 → 438
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:27 → 75
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:15 → 366
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      41649506..41778818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017352797.3 → XP_017208286.1  protein phosphatase 2, regulatory subunit B, beta b isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q610, A0A8M6Z3N4
      Related
      ENSDARP00000149529.1, ENSDART00000181539.1

    2. XM_021468863.2 → XP_021324538.1  protein phosphatase 2, regulatory subunit B, beta b isoform X2

      UniProtKB/TrEMBL
      A0A8M9PCQ6
      Related
      ENSDARP00000152523.1, ENSDART00000192669.1
      Conserved Domains (2) summary
      COG5170
      Location:14 → 428
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:17 → 65
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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