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    abca7 ATP-binding cassette, sub-family A (ABC1), member 7 [ Danio rerio (zebrafish) ]

    Gene ID: 561460, updated on 4-Jan-2025

    Summary

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    Official Symbol
    abca7provided by ZNC
    Official Full Name
    ATP-binding cassette, sub-family A (ABC1), member 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050517-6
    See related
    AllianceGenome:ZFIN:ZDB-GENE-050517-6
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    abca1; zgc:172302
    Summary
    Predicted to enable ABC-type transporter activity; ATP binding activity; and ATP hydrolysis activity. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 9. Orthologous to human ABCA7 (ATP binding cassette subfamily A member 7). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See abca7 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (5584678..5659694)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (5638360..5713553)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch73-40i7.5 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene R3H domain containing 4 Neighboring gene AT-rich interactive domain 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. Hultqvist G, et al. PLoS One, 2012. PMID 22855693, Free PMC Article
    2. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343
    3. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Dean M, et al. Annu Rev Genomics Hum Genet, 2005. PMID 16124856
    4. Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. Ren J, et al. BMC Genomics, 2015 Jun 6. PMID 26047617, Free PMC Article
    5. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. Keatinge M, et al. PLoS Genet, 2021 Apr. PMID 33914736, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC172302

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase ABCA1
    Names
    ATP-binding cassette 1, sub-family A, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      5584678..5659694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305796.3 → XP_009304071.2  phospholipid-transporting ATPase ABCA1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B3V5
      Conserved Domains (1) summary
      cl28181
      Location:1 → 2220
      AAA; ATPases associated with a variety of cellular activities

    2. XM_001920827.8 → XP_001920862.5  phospholipid-transporting ATPase ABCA1 isoform X2

      UniProtKB/TrEMBL
      A0A8M1QLA5
      Conserved Domains (1) summary
      cl28181
      Location:1 → 2212
      AAA; ATPases associated with a variety of cellular activities
    Nucleotide Protein Strain
    Heading Accession and Version

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