U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    angpt2b angiopoietin 2b [ Danio rerio (zebrafish) ]

    Gene ID: 114408, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    angpt2bprovided by ZNC
    Official Full Name
    angiopoietin 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010817-2
    See related
    Ensembl:ENSDARG00000053906 AllianceGenome:ZFIN:ZDB-GENE-010817-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ang2; angpt2
    Summary
    Acts upstream of or within blood vessel development. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in head mesenchyme; heart; lymphatic system; pronephric glomerulus; and vascular endothelium. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See angpt2b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (35799693..35852418)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (36212573..36265298)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488447 Neighboring gene uncharacterized LOC137488448 Neighboring gene CUB and Sushi multiple domains 2 Neighboring gene uncharacterized LOC137488537 Neighboring gene si:dkey-164n2.1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Using Ultra-Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry-Based Chemometrics for the Identification of Anti-angiogenic Biflavonoids from Edible Garcinia Species. Li P, et al. J Agric Food Chem, 2017 Sep 27. PMID 28926234
    2. Anti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica. Yue GG, et al. Eur J Med Chem, 2013 Jan. PMID 23231968
    3. Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos. Li R, et al. Arterioscler Thromb Vasc Biol, 2014 Oct. PMID 25147335, Free PMC Article
    4. Development of the zebrafish lymphatic system requires VEGFC signaling. Küchler AM, et al. Curr Biol, 2006 Jun 20. PMID 16782017
    5. Mechanistic Study of the In Vitro and In Vivo Inhibitory Effects of Protocatechuic Acid and Syringic Acid on VEGF-Induced Angiogenesis. Hu J, et al. J Agric Food Chem, 2018 Jul 5. PMID 29886729

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    angiopoietin-2b
    Names
    angiopoietin 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131814.1 → NP_571889.1  angiopoietin-2b precursor

      See identical proteins and their annotated locations for NP_571889.1

      Status: PROVISIONAL

      Source sequence(s)
      AF379603
      UniProtKB/TrEMBL
      Q90Z18
      Related
      ENSDARP00000070502.4, ENSDART00000076023.5
      Conserved Domains (2) summary
      cd00087
      Location:274 → 487
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam14772
      Location:164 → 244
      NYD-SP28; Sperm tail

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      35799693..35852418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.