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    wdr33 WD repeat domain 33 [ Danio rerio (zebrafish) ]

    Gene ID: 449009, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wdr33provided by ZNC
    Official Full Name
    WD repeat domain 33provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040924-3
    See related
    Ensembl:ENSDARG00000018272 AllianceGenome:ZFIN:ZDB-GENE-040924-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110570
    Summary
    Predicted to act upstream of or within mRNA 3'-end processing. Predicted to be located in membrane. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human WDR33 (WD repeat domain 33). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See wdr33 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (5410447..5443681, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (5498552..5531825, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-184j22.2 Neighboring gene SFT2 domain containing 3 Neighboring gene dual specificity phosphatase 28 Neighboring gene protein C (inactivator of coagulation factors Va and VIIIa), a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Enhancer Trapping and Annotation in Zebrafish Mediated with Sleeping Beauty, piggyBac and Tol2 Transposons. Shen D, et al. Genes (Basel), 2018 Dec 13. PMID 30551672, Free PMC Article
    2. Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Despic V, et al. Genome Res, 2017 Jul. PMID 28381614, Free PMC Article
    3. Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Kalén M, et al. Chem Biol, 2009 Apr 24. PMID 19389629, Free PMC Article
    4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA 3' end processing protein WDR33
    Names
    FLJ11294-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024221.2 → NP_001019392.2  pre-mRNA 3' end processing protein WDR33 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks most 3' exons and has an alternate 3' segment, as compared to variant 1. The resulting isoform 2 is much shorter than isoform 1.
      Source sequence(s)
      CU571377
      UniProtKB/TrEMBL
      A0A8M1N6M2, U3JAJ0
      Related
      ENSDARP00000127258.1, ENSDART00000121641.3
      Conserved Domains (3) summary
      COG2319
      Location:127 → 290
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:122 → 158
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:119 → 205
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001194928.1 → NP_001181857.1  pre-mRNA 3' end processing protein WDR33 isoform 1

      See identical proteins and their annotated locations for NP_001181857.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the full-length transcript and encodes isoform 1.
      Source sequence(s)
      CU571377, FP016178
      UniProtKB/TrEMBL
      A0A8M3B6D6, F1QJZ5
      Related
      ENSDARP00000027484.8, ENSDART00000025131.10
      Conserved Domains (3) summary
      COG2319
      Location:121 → 405
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:121 → 402
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:122 → 159
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      5410447..5443681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297073.4 → XP_009295348.1  pre-mRNA 3' end processing protein WDR33 isoform X1

      See identical proteins and their annotated locations for XP_009295348.1

      UniProtKB/TrEMBL
      A0A8M3B6D6, F1QJZ5
      Related
      ENSDARP00000115996.2, ENSDART00000138885.4
      Conserved Domains (3) summary
      COG2319
      Location:121 → 405
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:121 → 402
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:122 → 159
      7WD40; WD40 repeat [structural motif]

    2. XM_005163232.5 → XP_005163289.1  pre-mRNA 3' end processing protein WDR33 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BAF0
      Conserved Domains (3) summary
      COG2319
      Location:121 → 405
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:121 → 402
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:122 → 159
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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