rasgrp4 RAS guanyl releasing protein 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rasgrp4provided by ZNC
Official Full Name: RAS guanyl releasing protein 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-050419-110
See related: Ensembl:ENSDARG00000061796 AllianceGenome:ZFIN:ZDB-GENE-050419-110
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-12o15.1
Summary: Predicted to enable calcium ion binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within lymph vessel development. Is expressed in caudal vein plexus; dorsal aorta; head; notochord; and posterior cardinal vein. Orthologous to human RASGRP4 (RAS guanyl releasing protein 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (35742838..35802484)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (35761575..35821475)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RasGRP1 has a critical role in lymphatic development in zebrafish
Title: The RAS guanyl nucleotide-releasing protein RasGRP1 is involved in lymphatic development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lymph vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RAS guanyl-releasing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044862.1 → NP_001038327.1 RAS guanyl-releasing protein 4

See identical proteins and their annotated locations for NP_001038327.1

Status: PROVISIONAL

Source sequence(s)

CR377223

UniProtKB/TrEMBL

A0A8M9PM49, F6P976, Q1L9A0

Related

ENSDARP00000082937.4, ENSDART00000088504.6

Conserved Domains (5) summary

cd06224
Location:58 → 162

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:194 → 430

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam00130
Location:537 → 586

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:473 → 519

EF-hand_7; EF-hand domain pair

cl08302
Location:475 → 524

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

35742838..35802484

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173660.5 → XP_005173717.1 RAS guanyl-releasing protein 4 isoform X5

See identical proteins and their annotated locations for XP_005173717.1

UniProtKB/TrEMBL

A0A8M2BKX7, A0A8M9PM49

Conserved Domains (5) summary

cd06224
Location:26 → 130

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:162 → 398

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam00130
Location:505 → 554

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:441 → 487

EF-hand_7; EF-hand domain pair

cl08302
Location:443 → 492

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_005173657.5 → XP_005173714.1 RAS guanyl-releasing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8M2BLA4, A0A8M9PM49

Conserved Domains (5) summary

cd06224
Location:58 → 162

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:194 → 430

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam00130
Location:537 → 586

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:473 → 519

EF-hand_7; EF-hand domain pair

cl08302
Location:475 → 524

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_005173659.5 → XP_005173716.1 RAS guanyl-releasing protein 4 isoform X4

UniProtKB/TrEMBL

A0A8M2BKY0, A0A8M9PM49

Conserved Domains (5) summary

cd06224
Location:58 → 162

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:194 → 430

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam00130
Location:537 → 586

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:473 → 519

EF-hand_7; EF-hand domain pair

cl08302
Location:475 → 524

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_005173658.5 → XP_005173715.1 RAS guanyl-releasing protein 4 isoform X3

UniProtKB/TrEMBL

A0A8M2BKX1, A0A8M9PM49

Conserved Domains (5) summary

cd06224
Location:58 → 162

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:194 → 430

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam00130
Location:537 → 586

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:473 → 519

EF-hand_7; EF-hand domain pair

cl08302
Location:475 → 524

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_009293782.4 → XP_009292057.1 RAS guanyl-releasing protein 4 isoform X2

UniProtKB/TrEMBL

A0A8M3AJR7, A0A8M9PM49

Conserved Domains (5) summary

cd06224
Location:57 → 161

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:193 → 429

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam00130
Location:536 → 585

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:472 → 518

EF-hand_7; EF-hand domain pair

cl08302
Location:474 → 523

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...