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    ndrg1a N-myc downstream regulated 1a [ Danio rerio (zebrafish) ]

    Gene ID: 792085, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndrg1aprovided by ZNC
    Official Full Name
    N-myc downstream regulated 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-34
    See related
    Ensembl:ENSDARG00000032849 AllianceGenome:ZFIN:ZDB-GENE-030826-34
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb775; ndrg1; ndrg1a-1; ndrg1a-2; zgc:63944; wu:fb60h02
    Summary
    Acts upstream of or within negative regulation of cellular response to hypoxia. Predicted to be active in cytoplasm. Is expressed in several structures, including caudal vein plexus; corpuscles of Stannius; integument; pleuroperitoneal region; and visual system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ndrg1a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (34959967..34979837, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (35372847..35392717, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene Src like adaptor 1a Neighboring gene cellular communication network factor 4a Neighboring gene si:rp71-45k5.2 Neighboring gene zgc:113424

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish NDRG1a Negatively Regulates IFN Induction by Promoting the Degradation of IRF7. Lu LF, et al. J Immunol, 2019 Jan 1. PMID 30504422
    2. EpCAM controls morphogenetic programs during zebrafish pronephros development. Kuechlin S, et al. Biochem Biophys Res Commun, 2017 May 27. PMID 28411024
    3. Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family. Le N, et al. FASEB J, 2021 Nov. PMID 34665878, Free PMC Article
    4. Effects of NDRG1 family proteins on photoreceptor outer segment morphology in zebrafish. Takita S, et al. Sci Rep, 2016 Nov 4. PMID 27811999, Free PMC Article
    5. N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. Park JS, et al. Elife, 2022 Oct 10. PMID 36214665, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63944

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein NDRG1a
    Names
    N-myc downstream regulated gene 1
    N-myc downstream regulated gene 1a
    n-myc downstream-regulated gene 1a-1
    n-myc downstream-regulated gene 1a-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128353.1 → NP_001121825.1  protein NDRG1a isoform 1

      Status: PROVISIONAL

      Source sequence(s)
      CT573122
      UniProtKB/TrEMBL
      A0A146JRA4, A5WW18
      Related
      ENSDARP00000093670.4, ENSDART00000102896.6
      Conserved Domains (2) summary
      COG0596
      Location:17 → 297
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:18 → 302
      Ndr; Ndr family

    2. NM_213348.3 → NP_998513.2  protein NDRG1a isoform 2

      See identical proteins and their annotated locations for NP_998513.2

      Status: PROVISIONAL

      Source sequence(s)
      CT573122
      UniProtKB/TrEMBL
      A0A146JRC8, Q6A3P5
      Related
      ENSDARP00000044837.6, ENSDART00000044838.8
      Conserved Domains (2) summary
      COG0596
      Location:48 → 310
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:31 → 315
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      34959967..34979837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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