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    cog2 component of oligomeric golgi complex 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cog2provided by ZNC
    Official Full Name
    component of oligomeric golgi complex 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2671
    See related
    Ensembl:ENSDARG00000004037 AllianceGenome:ZFIN:ZDB-GENE-040426-2671
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zC8A9.2; zgc:56436
    Summary
    Predicted to be involved in Golgi organization and intra-Golgi vesicle-mediated transport. Predicted to act upstream of or within protein transport. Predicted to be located in Golgi apparatus and membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIq. Orthologous to human COG2 (component of oligomeric golgi complex 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cog2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (23996070..24018916, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (23865620..23888466, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene phosphatase and actin regulator 2 Neighboring gene angiotensinogen Neighboring gene piggyBac transposable element derived 5 Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A new evolutionary model for the vertebrate actin family including two novel groups. Witjes L, et al. Mol Phylogenet Evol, 2019 Dec. PMID 31560986
    2. An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. Postlethwait JH, et al. bioRxiv, 2020 Sep 2. PMID 32908984, Free PMC Article
    3. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    conserved oligomeric Golgi complex subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213354.1 → NP_998519.1  conserved oligomeric Golgi complex subunit 2

      See identical proteins and their annotated locations for NP_998519.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049314
      UniProtKB/TrEMBL
      Q7ZUD7
      Related
      ENSDARP00000024817.6, ENSDART00000026189.7
      Conserved Domains (2) summary
      pfam06148
      Location:11 → 143
      COG2; COG (conserved oligomeric Golgi) complex component, COG2
      pfam12022
      Location:564 → 689
      DUF3510; Domain of unknown function (DUF3510)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      23996070..24018916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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