ext1c exostoses (multiple) 1c [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ext1cprovided by ZNC
Official Full Name: exostoses (multiple) 1cprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050211-5
See related: AllianceGenome:ZFIN:ZDB-GENE-050211-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa93b07; wu:fa93b07; zgc:136662
Summary: Predicted to enable N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. Is expressed in brain; fin; otic vesicle; retina; and somite. Orthologous to human EXTL1 (exostosin like glycosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 19

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (47483174..47501781, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (47924914..47940794, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the three zebrafish ext1 genes encode proteoglycan modifying enzymes and have distinct relationships to somitic Sonic hedgehog signaling
Title: Distinct tissue-specificity of three zebrafish ext1 genes encoding proteoglycan modifying enzymes and their relationship to somitic Sonic hedgehog signaling.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fa93b07.x1 (e-PCR)
- UniSTS:202576

AI332072 (e-PCR)
- UniSTS:206781

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: exostosin-1c

Names: exostoses 1c; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1c; multiple exostoses protein 1 homolog c

NP_001035420.1

EC 2.4.1.224

EC 2.4.1.225

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040330.2 → NP_001035420.1 exostosin-1c

See identical proteins and their annotated locations for NP_001035420.1

Status: PROVISIONAL

Source sequence(s)

BC115216

UniProtKB/Swiss-Prot

Q5IGR6

UniProtKB/TrEMBL

Q1RLZ5

Conserved Domains (2) summary

pfam03016
Location:103 → 388

Exostosin; Exostosin family

pfam09258
Location:472 → 712

Glyco_transf_64; Glycosyl transferase family 64 domain