cnot1 CCR4-NOT transcription complex, subunit 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cnot1provided by ZNC
Official Full Name: CCR4-NOT transcription complex, subunit 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040915-1
See related: Ensembl:ENSDARG00000004174 AllianceGenome:ZFIN:ZDB-GENE-040915-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kiaa1007l; cdc39-like; im:7141761; wu:fc58h04; zgc:152902
Summary: Predicted to enable molecular adaptor activity; nuclear estrogen receptor binding activity; and nuclear retinoic acid receptor binding activity. Acts upstream of or within developmental growth. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Human ortholog(s) of this gene implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (17313568..17346929)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (17217168..17250529)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear estrogen receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear retinoic acid receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of retinoic acid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytoplasmic mRNA processing body assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	ISS Inferred from Sequence or Structural Similarity more info
part_of CCR4-NOT core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CCR4-NOT core complex	IEA Inferred from Electronic Annotation more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CCR4-NOT transcription complex subunit 1

Names: CCR4-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079951.2 → NP_001073420.1 CCR4-NOT transcription complex subunit 1

See identical proteins and their annotated locations for NP_001073420.1

Status: PROVISIONAL

Source sequence(s)

BC128655

UniProtKB/Swiss-Prot

A1A5H6, Q6DRB0

Related

ENSDARP00000111504.2, ENSDART00000125459.4

Conserved Domains (6) summary

pfam08430
Location:698 → 805

Forkhead_N; Forkhead N-terminal region

pfam04054
Location:1996 → 2351

Not1; CCR4-Not complex component, Not1

pfam12842
Location:1387 → 1532

DUF3819; Domain of unknown function (DUF3819)

pfam16415
Location:1080 → 1305

CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain

pfam16417
Location:812 → 996

CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain

pfam16418
Location:500 → 656

CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat