stil STIL centriolar assembly protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stilprovided by ZNC
Official Full Name: STIL centriolar assembly proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020419-39
See related: Ensembl:ENSDARG00000024904 AllianceGenome:ZFIN:ZDB-GENE-020419-39
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: csp; nbb; sill; chunp6907; zgc:110502
Summary: Acts upstream of or within several processes, including neuron cellular homeostasis; smoothened signaling pathway; and spindle organization. Predicted to be located in centriole. Predicted to be active in microtubule organizing center. Is expressed in several structures, including gut; heart; nervous system; optic cup; and pronephros. Used to study microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 7. Orthologous to human STIL (STIL centriolar assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (15959901..15972522)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (15933631..15946252)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

decreased expression of Stil resulted in increased toxic susceptibility of retinal dopaminergic cells to 6-hydroxydopamine
Title: Functional expression of SCL/TAL1 interrupting locus (Stil) protects retinal dopaminergic cells from neurotoxin-induced degeneration.
These data, taken together, identify SIL as a novel, vertebrate-specific regulator of mitotic spindle assembly.
Title: The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.
Scl/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other
Title: The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within body morphogenesis	IMP Inferred from Mutant Phenotype more info
involved_in microtubule organizing center organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to centrosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of centriole replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SCL-interrupting locus protein homolog

Names: TAL1 (SCL) interrupting locus like; cassiopeia; scl/tal1 interrupting locus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173244.2 → NP_775351.2 SCL-interrupting locus protein homolog

Status: VALIDATED

Source sequence(s)

BM530920, BX908392, EH591838

UniProtKB/Swiss-Prot

Q1LV59, Q58EB7, Q8JGS1

UniProtKB/TrEMBL

A0A8M6Z3C1

Related

ENSDARP00000037419.6, ENSDART00000033617.7

Conserved Domains (1) summary

pfam15253
Location:47 → 448

STIL_N; SCL-interrupting locus protein N-terminus