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    etv5a ETS variant transcription factor 5a [ Danio rerio (zebrafish) ]

    Gene ID: 337626, updated on 15-Dec-2024

    Summary

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    Official Symbol
    etv5aprovided by ZNC
    Official Full Name
    ETS variant transcription factor 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9572
    See related
    Ensembl:ENSDARG00000069763 AllianceGenome:ZFIN:ZDB-GENE-030131-9572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    etv5; fj87h10; zgc:55647; id:ibd5133; wu:fj87h10
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including hemangioblast cell differentiation; limb morphogenesis; and pronephric nephron tubule epithelial cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including mesoderm; nervous system; neural tube; pronephros; and tail bud. Orthologous to human ETV5 (ETS variant transcription factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See etv5a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (22631787..22649027)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (22820918..22838158)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase beta-like Neighboring gene crystallin, gamma S3 Neighboring gene RNA binding motif protein 44 Neighboring gene integrin, beta 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Divergence in regulation of the PEA3 family of ETS transcription factors. Roussigné M, et al. Gene Expr Patterns, 2006 Oct. PMID 16516559
    2. Prostaglandin signaling regulates renal multiciliated cell specification and maturation. Marra AN, et al. Proc Natl Acad Sci U S A, 2019 Apr 23. PMID 30948642, Free PMC Article
    3. Activity of etv5a and etv5b genes in the hypothalamus of fasted zebrafish is influenced by serotonin. Mechaly AS, et al. Gen Comp Endocrinol, 2017 May 15. PMID 28041791
    4. Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish. Spiró Z, et al. Sci Rep, 2016 Jun 7. PMID 27273160, Free PMC Article
    5. Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development. Marra AN, et al. Dev Biol, 2016 Mar 15. PMID 26827902, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. etv5a and etv4 have roles in mediating epithelial cell fate during zebrafish kidney development
      Title: Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development.
    2. Zebrafish etv5a is essential for the inhibition of ventral mesoderm cell proliferation and for the formation of the hemato-vascular lineage.
      Title: Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hemangioblast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephric nephron tubule epithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephric nephron tubule epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ETS translocation variant 5a
    Names
    ets variant gene 5 (ets-related molecule)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126461.2 → NP_001119933.1  ETS translocation variant 5a isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX548053
      UniProtKB/TrEMBL
      A0A8M9PRX2, B0S6S7
      Related
      ENSDARP00000108566.2, ENSDART00000126015.4
      Conserved Domains (2) summary
      smart00413
      Location:376 → 462
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:2 → 375
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    2. NM_001328592.1 → NP_001315521.1  ETS translocation variant 5a isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX548053
      UniProtKB/TrEMBL
      A0A8M1P578, F1Q6X6
      Related
      ENSDARP00000092546.5, ENSDART00000101770.5
      Conserved Domains (2) summary
      smart00413
      Location:376 → 460
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:1 → 375
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      22631787..22649027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478613.2 → XP_021334288.1  ETS translocation variant 5a isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q4H5
      Conserved Domains (2) summary
      smart00413
      Location:375 → 461
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:2 → 374
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    2. XM_021478614.2 → XP_021334289.1  ETS translocation variant 5a isoform X3

      UniProtKB/TrEMBL
      A0A8M9QAL5
      Conserved Domains (2) summary
      smart00413
      Location:375 → 459
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:2 → 374
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    3. XM_021478612.2 → XP_021334287.1  ETS translocation variant 5a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PRX2, B0S6S7
      Related
      ENSDARP00000156093.1, ENSDART00000181822.1
      Conserved Domains (2) summary
      smart00413
      Location:376 → 462
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:2 → 375
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394751.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      444360..461600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395279.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      168425..186316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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