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    gigyf2 GRB10 interacting GYF protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 561830, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gigyf2provided by ZNC
    Official Full Name
    GRB10 interacting GYF protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050706-185
    See related
    Ensembl:ENSDARG00000009735 AllianceGenome:ZFIN:ZDB-GENE-050706-185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gigfy2; fb57e02; im:6911549; wu:fb57e02; zgc:111944
    Summary
    Predicted to be involved in insulin-like growth factor receptor signaling pathway. Predicted to be active in several cellular components, including cytosol; perikaryon; and proximal dendrite. Is expressed in blastoderm; blastodisc; brain; and somite. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gigyf2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (48203278..48255847, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (48349027..48401701, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene G-protein coupled receptor 55 Neighboring gene uncharacterized LOC137488208 Neighboring gene lysophosphatidic acid receptor 5a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutational screening and zebrafish functional analysis of GIGYF2 as a Parkinson-disease gene. Guella I, et al. Neurobiol Aging, 2011 Nov. PMID 20060621
    2. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease in zebrafish. Sarath Babu N, et al. Proteomics, 2016 May. PMID 26959078
    3. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111944

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in proximal dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GRB10-interacting GYF protein 2
    Names
    PERQ amino acid-rich with GYF domain-containing protein 2
    trinucleotide repeat-containing gene 15 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030161.2 → NP_001025332.2  GRB10-interacting GYF protein 2

      Status: VALIDATED

      Source sequence(s)
      BX677676, BX890560, BX890608
      UniProtKB/Swiss-Prot
      B0S7J5, Q4KME6
      Related
      ENSDARP00000056276.5, ENSDART00000056277.6
      Conserved Domains (1) summary
      smart00444
      Location:557 → 612
      GYF; Contains conserved Gly-Tyr-Phe residues

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      48203278..48255847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358654.3 → XP_017214143.1  GRB10-interacting GYF protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z920

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394514.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      279401..301823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KME6.2 GenPept UniProtKB/Swiss-Prot:Q4KME6

    Gene LinkOut

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