rbfox1 RNA binding fox-1 homolog 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rbfox1provided by ZNC
Official Full Name: RNA binding fox-1 homolog 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040927-11
See related: Ensembl:ENSDARG00000014746 AllianceGenome:ZFIN:ZDB-GENE-040927-11
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fox1; a2bp1; zgc:103635
Summary: Predicted to enable mRNA binding activity. Acts upstream of or within several processes, including left ventricular cardiac muscle tissue morphogenesis; regulation of alternative mRNA splicing, via spliceosome; and swimming behavior. Predicted to be active in cytoplasm and nucleus. Is expressed in digestive system; heart; nervous system; neural keel; and skeletal muscle. Orthologous to human RBFOX1 (RNA binding fox-1 homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (27986067..28427927, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (27853320..28297356, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models.
Title: Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in two zebrafish models.
This study underlines that tightly regulated splicing is necessary for unconstrained cardiac function and renders the splicing regulator rbfox1 an interesting target for investigation in human heart failure and cardiomyopathy.
Title: RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish.

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General gene information

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Markers

Z963 (e-PCR)
- UniSTS:10531

z963 (e-PCR), detects polymorphism
- UniSTS:238219

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypothalamus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within left ventricular cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA binding protein fox-1 homolog 1

Names: ataxin-2-binding protein 1; fox-1 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005596.1 → NP_001005596.1 RNA binding protein fox-1 homolog 1

See identical proteins and their annotated locations for NP_001005596.1

Status: PROVISIONAL

Source sequence(s)

BC081500

UniProtKB/Swiss-Prot

Q642J5

UniProtKB/TrEMBL

A0A8M9PY74

Related

ENSDARP00000107099.2, ENSDART00000122037.4

Conserved Domains (3) summary

COG0724
Location:115 → 202

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12407
Location:119 → 194

RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins

pfam12414
Location:228 → 318

Fox-1_C; Calcitonin gene-related peptide regulator C terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

27986067..28427927 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068216728.1 → XP_068072829.1 RNA binding protein fox-1 homolog 1 isoform X13

UniProtKB/TrEMBL

A0A8M9PY74
XM_068216731.1 → XP_068072832.1 RNA binding protein fox-1 homolog 1 isoform X15

UniProtKB/TrEMBL

A0A8M9PY89
XM_068216726.1 → XP_068072827.1 RNA binding protein fox-1 homolog 1 isoform X12

UniProtKB/TrEMBL

A0A8M9PMK8
XM_068216714.1 → XP_068072815.1 RNA binding protein fox-1 homolog 1 isoform X2

UniProtKB/TrEMBL

A0A8M9PY74
XM_068216717.1 → XP_068072818.1 RNA binding protein fox-1 homolog 1 isoform X4

UniProtKB/TrEMBL

A0A8M9PUS3
XM_068216722.1 → XP_068072823.1 RNA binding protein fox-1 homolog 1 isoform X8

UniProtKB/TrEMBL

A0A8M9PY79
XM_017354041.3 → XP_017209530.1 RNA binding protein fox-1 homolog 1 isoform X3

UniProtKB/TrEMBL

A0A8M6YWH2, A0A8M9PY70
XM_017354044.3 → XP_017209533.1 RNA binding protein fox-1 homolog 1 isoform X7

UniProtKB/TrEMBL

A0A8M6Z4X9, A0A8M9PY70
XM_017354045.3 → XP_017209534.1 RNA binding protein fox-1 homolog 1 isoform X9

UniProtKB/TrEMBL

A0A8M6YVW0, A0A8M9PY70
XM_068216725.1 → XP_068072826.1 RNA binding protein fox-1 homolog 1 isoform X11

UniProtKB/TrEMBL

A0A8M9P6C2
XM_068216724.1 → XP_068072825.1 RNA binding protein fox-1 homolog 1 isoform X10

UniProtKB/TrEMBL

A0A8M9PUS8
XM_068216718.1 → XP_068072819.1 RNA binding protein fox-1 homolog 1 isoform X5

UniProtKB/TrEMBL

A0A8M9P6B9
XM_068216713.1 → XP_068072814.1 RNA binding protein fox-1 homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8M9PY70
XM_017354049.3 → XP_017209538.1 RNA binding protein fox-1 homolog 1 isoform X14

UniProtKB/TrEMBL

A0A8M6YWH6, A0A8M9PY70
XM_017354043.3 → XP_017209532.1 RNA binding protein fox-1 homolog 1 isoform X6

UniProtKB/TrEMBL

A0A8M6YYC7, A0A8M9PY70