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    alpi.1 alkaline phosphatase, intestinal, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 541539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpi.1provided by ZNC
    Official Full Name
    alkaline phosphatase, intestinal, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050327-78
    See related
    Ensembl:ENSDARG00000015273 AllianceGenome:ZFIN:ZDB-GENE-050327-78
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    alpi; im:7149588; wu:fa95f04; zgc:110794; si:ch211-262h13.1
    Summary
    Predicted to enable alkaline phosphatase activity. Predicted to be located in side of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including floor plate; intestine; median fin fold; periderm; and segmental plate. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpi.1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (38762813..38778038)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (38776068..38791293)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene si:ch211-126j24.1 Neighboring gene natriuretic peptide C Neighboring gene uncharacterized LOC137488978 Neighboring gene uncharacterized LOC137488979 Neighboring gene alkaline phosphatase, intestinal, tandem duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamic Evolution of the LPS-Detoxifying Enzyme Intestinal Alkaline Phosphatase in Zebrafish and Other Vertebrates. Yang Y, et al. Front Immunol, 2012. PMID 23091474, Free PMC Article
    2. Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Bates JM, et al. Cell Host Microbe, 2007 Dec 13. PMID 18078689, Free PMC Article
    3. The Effects of Plant Protein-Enriched Live Food on Larval Zebrafish Growth and the Status of Its Digestive Tract Development. Schwepe CW, et al. Zebrafish, 2022 Dec. PMID 36367699
    4. Dynamic Lkb1-TORC1 signaling as a possible mechanism for regulating the endoderm-intestine transition. Marshall KE, et al. Dev Dyn, 2010 Nov. PMID 20925120, Free PMC Article
    5. Soybean Meal and Soy Protein Concentrate in Early Diet Elicit Different Nutritional Programming Effects on Juvenile Zebrafish. Perera E, et al. Zebrafish, 2016 Feb. PMID 26716770

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alkaline phosphatase, intestinal, tandem duplicate 1
    Names
    alkaline phosphatase, intestinal.1
    iap
    intestinal alkaline phosphatase 1
    NP_001014375.1
    XP_009294806.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014353.1 → NP_001014375.1  alkaline phosphatase, intestinal, tandem duplicate 1 precursor

      See identical proteins and their annotated locations for NP_001014375.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091940
      UniProtKB/TrEMBL
      Q58EF1
      Related
      ENSDARP00000016216.10, ENSDART00000015016.10
      Conserved Domains (2) summary
      COG1785
      Location:46 → 493
      PhoA; Alkaline phosphatase [Inorganic ion transport and metabolism, General function prediction only]
      pfam00245
      Location:61 → 496
      Alk_phosphatase; Alkaline phosphatase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      38762813..38778038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296531.3 → XP_009294806.1  alkaline phosphatase, intestinal, tandem duplicate 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B5T5
      Conserved Domains (1) summary
      pfam00245
      Location:28 → 417
      Alk_phosphatase; Alkaline phosphatase
    Nucleotide Protein Strain
    Heading Accession and Version

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