xrn2 5'-3' exoribonuclease 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: xrn2provided by ZNC
Official Full Name: 5'-3' exoribonuclease 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2874
See related: Ensembl:ENSDARG00000101900 AllianceGenome:ZFIN:ZDB-GENE-040426-2874
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55717; wu:fb38g12; wu:fj53d06
Summary: Predicted to enable 5'-3' RNA exonuclease activity and RNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma and lung cancer. Orthologous to human XRN2 (5'-3' exoribonuclease 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (48810491..48898560, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (48979274..49067343, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 5'-3' RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-3' RNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA exonuclease activity, producing 5'-phosphomonoesters	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5'-3' exoribonuclease 2

NP_001001944.2

EC 3.1.13.-

XP_005160932.1

EC 3.1.13.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001944.2 → NP_001001944.2 5'-3' exoribonuclease 2

Status: VALIDATED

Source sequence(s)

BX005124, CT573061

UniProtKB/TrEMBL

A0A0R4ISJ3, A0A8M1MZQ7

Related

ENSDARP00000138850.1, ENSDART00000163071.2

Conserved Domains (2) summary

COG5049
Location:1 → 796

XRN1; 5'-3' exonuclease [Replication, recombination and repair]

pfam03159
Location:1 → 253

XRN_N; XRN 5'-3' exonuclease N-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

48810491..48898560 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160875.5 → XP_005160932.1 5'-3' exoribonuclease 2 isoform X1

UniProtKB/TrEMBL

A0A8M2B7S3

Conserved Domains (2) summary

COG5049
Location:1 → 782

XRN1; 5'-3' exonuclease [Replication, recombination and repair]

pfam03159
Location:1 → 253

XRN_N; XRN 5'-3' exonuclease N-terminus