map2k4a mitogen-activated protein kinase kinase 4a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: map2k4aprovided by ZNC
Official Full Name: mitogen-activated protein kinase kinase 4aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060512-98
See related: Ensembl:ENSDARG00000063583 AllianceGenome:ZFIN:ZDB-GENE-060512-98
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MKK4; map2k4; MKK4A-l; zgc:136500
Summary: Predicted to enable JUN kinase kinase activity. Acts upstream of or within determination of dorsal identity. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (10592597..10634496, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (10626051..10667999, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dual specificity mitogen-activated protein kinase kinase 4a

Names: mitogen-activated protein kinase kinase 4; mkk4a

NP_991299.2

EC 2.7.1.-

XP_005164412.1

EC 2.7.1.-

XP_009297453.1

EC 2.7.1.-

XP_068072408.1

EC 2.7.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205736.2 → NP_991299.2 dual specificity mitogen-activated protein kinase kinase 4a

See identical proteins and their annotated locations for NP_991299.2

Status: PROVISIONAL

Source sequence(s)

EF433293

UniProtKB/TrEMBL

A0A8M1PH96, B1NA68

Related

ENSDARP00000106153.1, ENSDART00000130761.4

Conserved Domains (2) summary

smart00220
Location:108 → 372

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06616
Location:101 → 390

PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

10592597..10634496 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164355.5 → XP_005164412.1 dual specificity mitogen-activated protein kinase kinase 4a isoform X2

UniProtKB/TrEMBL

A0A8M2BBT8

Conserved Domains (2) summary

smart00220
Location:93 → 357

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06616
Location:86 → 375

PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
XM_009299178.4 → XP_009297453.1 dual specificity mitogen-activated protein kinase kinase 4a isoform X1

UniProtKB/TrEMBL

A0A8M3B0Q3

Conserved Domains (2) summary

smart00220
Location:97 → 361

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06616
Location:90 → 379

PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
XM_068216307.1 → XP_068072408.1 dual specificity mitogen-activated protein kinase kinase 4a isoform X3