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    Sephs1 selenophosphate synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 109079, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sephs1provided by MGI
    Official Full Name
    selenophosphate synthetase 1provided by MGI
    Primary source
    MGI:MGI:1923580
    See related
    Ensembl:ENSMUSG00000026662 AllianceGenome:MGI:1923580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPS; SELD; SPS1; 1110046B24Rik
    Summary
    Predicted to enable protein heterodimerization activity; protein homodimerization activity; and selenide, water dikinase activity. Predicted to be involved in selenocysteine biosynthetic process. Predicted to be located in nuclear membrane and plasma membrane. Predicted to be active in cytoplasm. Is expressed in central nervous system; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human SEPHS1 (selenophosphate synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.5), limb E14.5 (RPKM 14.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sephs1 in Genome Data Viewer
    Location:
    2 A1; 2 3.02 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (4886375..4915368)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (4881564..4910557)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene BEN domain containing 7 Neighboring gene predicted gene, 36389 Neighboring gene protein regulator of cytokinesis 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9503 Neighboring gene predicted gene, 46728 Neighboring gene phytanoyl-CoA hydroxylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables selenide, water dikinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables selenide, water dikinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in selenocysteine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    selenide, water dikinase 1
    Names
    selenium donor protein 1
    selenophosphate synthase 1
    NP_001349636.1
    NP_001349637.1
    NP_001349638.1
    NP_001349639.1
    NP_780609.4
    XP_036013392.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362707.1NP_001349636.1  selenide, water dikinase 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK053638, BC066037, CJ173995
      Consensus CDS
      CCDS15659.1
      UniProtKB/Swiss-Prot
      Q8BH69
      UniProtKB/TrEMBL
      Q6NZN9, Q6P1B6
      Related
      ENSMUSP00000110671.2, ENSMUST00000115019.2
      Conserved Domains (1) summary
      TIGR00476
      Location:19333
      selD; selenium donor protein
    2. NM_001362708.1NP_001349637.1  selenide, water dikinase 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL807778
      Consensus CDS
      CCDS15659.1
      UniProtKB/Swiss-Prot
      Q8BH69
      UniProtKB/TrEMBL
      Q6NZN9, Q6P1B6
      Conserved Domains (1) summary
      TIGR00476
      Location:19333
      selD; selenium donor protein
    3. NM_001362709.1NP_001349638.1  selenide, water dikinase 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL807778
      UniProtKB/TrEMBL
      Q6NZN9, Q6P1B6
      Conserved Domains (1) summary
      TIGR00476
      Location:19297
      selD; selenium donor protein
    4. NM_001362710.1NP_001349639.1  selenide, water dikinase 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate coding exon in the 5' end compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL807778
      Conserved Domains (1) summary
      cl10019
      Location:28287
      PurM-like; AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain ...
    5. NM_175400.6NP_780609.4  selenide, water dikinase 1 isoform a

      See identical proteins and their annotated locations for NP_780609.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      BC065165, BC066037
      Consensus CDS
      CCDS15659.1
      UniProtKB/Swiss-Prot
      Q8BH69
      UniProtKB/TrEMBL
      Q6NZN9, Q6P1B6
      Related
      ENSMUSP00000027973.8, ENSMUST00000027973.14
      Conserved Domains (1) summary
      TIGR00476
      Location:19333
      selD; selenium donor protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      4886375..4915368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157499.1XP_036013392.1  selenide, water dikinase 1 isoform X1

      Conserved Domains (1) summary
      cl10019
      Location:28287
      PurM-like; AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain ...