U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    TLR3 toll like receptor 3 [ Homo sapiens (human) ]

    Gene ID: 7098, updated on 4-Jan-2025

    Summary

    Official Symbol
    TLR3provided by HGNC
    Official Full Name
    toll like receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:11849
    See related
    Ensembl:ENSG00000164342 MIM:603029; AllianceGenome:HGNC:11849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD283; IIAE2; IMD83
    Summary
    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in duodenum (RPKM 5.4), small intestine (RPKM 5.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TLR3 in Genome Data Viewer
    Location:
    4q35.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (186069156..186088073)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (189409568..189428483)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (186990310..187009227)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900830 Neighboring gene uncharacterized LOC124900829 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:186948264-186949463 Neighboring gene RNA, U4 small nuclear 64, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15857 Neighboring gene uncharacterized LOC124900171 Neighboring gene family with sequence similarity 149 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:187064906-187065406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:187065407-187065907 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:187069874-187071073 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:187071092-187071287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:187079637-187080136 Neighboring gene ribosomal protein SA pseudogene 70

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication is restricted by TLR3 stimulation in Langerhans cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables double-stranded RNA binding  
    enables double-stranded RNA binding PubMed 
    enables double-stranded RNA binding PubMed 
    enables identical protein binding PubMed 
    enables pattern recognition receptor activity PubMed 
    enables protein binding PubMed 
    enables signaling receptor activity  
    enables transmembrane signaling receptor activity PubMed 
    enables ubiquitin-like protein ligase binding  
    Items 1 - 25 of 49
    Process Evidence Code Pubs
    involved_in I-kappaB phosphorylation PubMed 
    involved_in JNK cascade  
    involved_in activation of NF-kappaB-inducing kinase activity PubMed 
    involved_in cellular response to exogenous dsRNA  
    involved_in cellular response to interferon-beta  
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in cellular response to type II interferon  
    involved_in cellular response to virus  
    involved_in cellular response to xenobiotic stimulus  
    involved_in defense response to bacterium PubMed 
    involved_in defense response to virus PubMed 
    involved_in defense response to virus PubMed 
    involved_in detection of virus PubMed 
    involved_in extrinsic apoptotic signaling pathway PubMed 
    involved_in hyperosmotic response PubMed 
    involved_in inflammatory response to wounding PubMed 
    involved_in innate immune response PubMed 
    involved_in male gonad development  
    involved_in microglial cell activation  
    involved_in necroptotic signaling pathway PubMed 
    involved_in negative regulation of osteoclast differentiation PubMed 
    involved_in positive regulation of JNK cascade PubMed 
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of chemokine production PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of inflammatory response PubMed 
    involved_in positive regulation of interferon-alpha production PubMed 
    involved_in positive regulation of interferon-beta production PubMed 
    involved_in positive regulation of interferon-beta production PubMed 
    involved_in positive regulation of interferon-beta production  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of interleukin-6 production PubMed 
    acts_upstream_of positive regulation of interleukin-8 production PubMed 
    involved_in positive regulation of macrophage cytokine production  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type II interferon production PubMed 
    involved_in positive regulation of type III interferon production  
    involved_in regulation of dendritic cell cytokine production  
    involved_in response to dsRNA  
    acts_upstream_of_or_within response to exogenous dsRNA PubMed 
    involved_in signal transduction PubMed 
    involved_in toll-like receptor 3 signaling pathway PubMed 
    involved_in toll-like receptor signaling pathway PubMed 
    involved_in type III interferon production  
    Items 1 - 25 of 49
    Component Evidence Code Pubs
    located_in Golgi membrane  
    NOT located_in cell surface PubMed 
    located_in cytoplasm PubMed 
    is_active_in early endosome PubMed 
    located_in endolysosome membrane  
    located_in endoplasmic reticulum membrane  
    is_active_in endosome membrane PubMed 
    located_in endosome membrane  
    is_active_in extracellular matrix  
    is_active_in extracellular space  
    located_in lysosomal membrane PubMed 
    located_in membrane PubMed 
    located_in plasma membrane  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007278.1 RefSeqGene

      Range
      5001..20944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_117

    mRNA and Protein(s)

    1. NM_003265.3 → NP_003256.1  toll-like receptor 3 precursor

      See identical proteins and their annotated locations for NP_003256.1

      Status: REVIEWED

      Source sequence(s)
      AC104070, BC096333, BU624267, DA374150, U88879
      Consensus CDS
      CCDS3846.1
      UniProtKB/Swiss-Prot
      B2RAI7, B7Z7K0, E6Y0F0, E6Y0F1, E9PGH4, O15455, Q4VAL2, Q504W0
      UniProtKB/TrEMBL
      Q6PCD4
      Related
      ENSP00000296795.3, ENST00000296795.8
      Conserved Domains (7) summary
      smart00082
      Location:645 → 697
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:755 → 900
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:72 → 542
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:33 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:28 → 50
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:562 → 622
      LRR_8; Leucine rich repeat
      pfam17968
      Location:698 → 730
      Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      186069156..186088073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      189409568..189428483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Loading
    Loading
    External link. Please review our privacy policy.