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    ymel-1 ATP-dependent zinc metalloprotease YME1 homolog [ Caenorhabditis elegans ]

    Gene ID: 176460, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ymel-1
    Official Full Name
    ATP-dependent zinc metalloprotease YME1 homolog
    Primary source
    WormBase:WBGene00010842
    Locus tag
    CELE_M03C11.5
    See related
    AllianceGenome:WB:WBGene00010842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in optic atrophy 11. Orthologous to human YME1L1 (YME1 like 1 ATPase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ymel-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (10416139..10421757)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ATP-dependent DNA helicase chl-1 Neighboring gene PH domain-containing protein Neighboring gene Histone acetyltransferase type B catalytic subunit Neighboring gene BBS2_C domain-containing protein Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. van Ham TJ, et al. PLoS Genet, 2008 Mar 21. PMID 18369446, Free PMC Article
    2. Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans. Pandey T, et al. Exp Gerontol, 2019 Jun. PMID 30825547
    3. Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1. Sharma S, et al. Mol Neurobiol, 2021 Jan. PMID 32894501
    4. A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity. Monaghan RM, et al. Nat Cell Biol, 2015 Jun. PMID 25961505, Free PMC Article
    5. NAD(+) boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Romani M, et al. Cell Rep, 2021 Jan 19. PMID 33472069, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of m-AAA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent zinc metalloprotease YME1 homolog
    NP_001366715.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10416139..10421757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379892.2 → NP_001366715.1  ATP-dependent zinc metalloprotease YME1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54813
      Conserved Domains (1) summary
      TIGR01241
      Location:195 → 685
      FtsH_fam; ATP-dependent metalloprotease FtsH
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54813.2

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