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    ins-18 INSulin related [ Caenorhabditis elegans ]

    Gene ID: 172600, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ins-18
    Official Full Name
    INSulin related
    Primary source
    WormBase:WBGene00002101
    Locus tag
    CELE_T28B8.2
    See related
    AllianceGenome:WB:WBGene00002101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in maintenance of dauer; negative regulation of insulin receptor signaling pathway; and regulation of dauer entry. Is expressed in several structures, including coelomocyte; gonad; head muscle; neurons; and somatic nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ins-18 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (8147427..8149651)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Amiloride-sensitive sodium channel Neighboring gene Secreted protein Neighboring gene DUF3437 domain-containing protein;Proteasome activator complex subunit 4 C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a Caenorhabditis elegans cDNA encoding a new insulin/IGF-like peptide. Kawano T, et al. Biosci Biotechnol Biochem, 2003 Dec. PMID 14730154
    2. Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. Kawano T, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873623
    3. Comparison of physiological functions of antagonistic insulin-like peptides, INS-23 and INS-18, in Caenorhabditis elegans. Matsunaga Y, et al. Biosci Biotechnol Biochem, 2018 Jan. PMID 29303423
    4. Feeding state regulates pheromone-mediated avoidance behavior via the insulin signaling pathway in Caenorhabditis elegans. Ryu L, et al. EMBO J, 2018 Aug 1. PMID 29925517, Free PMC Article
    5. Identification and analysis of insulin like peptides in nematode secretomes provide targets for parasite control. Gahoi S, et al. Bioinformation, 2016. PMID 28356679, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data suggests that INS-18 is a DAF-2 antagonist that functions mainly in nerve cells.
      Title: Physiological function, expression pattern, and transcriptional regulation of a Caenorhabditis elegans insulin-like peptide, INS-18.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in maintenance of dauer IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dauer entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    INSulin related
    NP_001379200.1
    • Product from WormBase gene class ins;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8147427..8149651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392642.1 → NP_001379200.1  INSulin related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECC6
    Nucleotide Protein
    Heading Accession and Version

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