cht-1 putative endochitinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cht-1
Official Full Name: putative endochitinase
Primary source: WormBase:WBGene00000503
Locus tag: CELE_C04F6.3
See related: AllianceGenome:WB:WBGene00000503
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables chitinase activity. Involved in chitin catabolic process and response to fungus. Predicted to be active in extracellular region. Is expressed in gonad. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cht-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (3397613..3400017, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal Structure and Structure-Based Discovery of Inhibitors of the Nematode Chitinase CeCht1.
Title: Crystal Structure and Structure-Based Discovery of Inhibitors of the Nematode Chitinase CeCht1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C04F6.3 (e-PCR)
- UniSTS:306115

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables chitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables chitinase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATF6-mediated unfolded protein response	HEP more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in chitin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in polysaccharide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to fungus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative endochitinase

NP_508588.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

3397613..3400017 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076187.5 → NP_508588.1 putative endochitinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508588.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17321, Q11174

Conserved Domains (3) summary

cd02872
Location:55 → 423

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

smart00636
Location:57 → 399

Glyco_18; Glyco_18 domain

pfam01607
Location:567 → 615

CBM_14; Chitin binding Peritrophin-A domain