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    C14C10.5 Proteasome activator complex subunit 4 [ Caenorhabditis elegans ]

    Gene ID: 179726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C14C10.5
    Official Full Name
    Proteasome activator complex subunit 4
    Primary source
    WormBase:WBGene00007588
    Locus tag
    CELE_C14C10.5
    See related
    AllianceGenome:WB:WBGene00007588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in proteasomal ubiquitin-independent protein catabolic process. Predicted to be part of proteasome complex. Predicted to be active in cytosol and nucleus. Is expressed in pharynx. Orthologous to human PSME4 (proteasome activator subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C14C10.5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (12600192..12607304)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNAi-Induced Longevity Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene putative ergosterol biosynthetic protein 28 homolog Neighboring gene Conserved secreted protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasomal ubiquitin-independent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Proteasome activator complex subunit 4
    NP_001294711.1
    • Confirmed by transcript evidence
    NP_506153.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12600192..12607304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073752.4 → NP_506153.1  Proteasome activator complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17971
      Conserved Domains (2) summary
      pfam11919
      Location:1821 → 1907
      DUF3437; Domain of unknown function (DUF3437)
      pfam16507
      Location:369 → 847
      BLM10_mid; Proteasome-substrate-size regulator, mid region

    2. NM_001307782.2 → NP_001294711.1  Proteasome activator complex subunit 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NTN5
      Conserved Domains (2) summary
      pfam11919
      Location:1805 → 1891
      DUF3437; Domain of unknown function (DUF3437)
      pfam16507
      Location:353 → 831
      BLM10_mid; Proteasome-substrate-size regulator, mid region
    Nucleotide Protein
    Heading Accession and Version

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