rpb-2 DNA-directed RNA polymerase II subunit RPB2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rpb-2
Official Full Name: DNA-directed RNA polymerase II subunit RPB2
Primary source: WormBase:WBGene00016140
Locus tag: CELE_C26E6.4
See related: AllianceGenome:WB:WBGene00016140
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable several functions, including DNA-directed 5'-3' RNA polymerase activity; metal ion binding activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase II activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II, core complex. Is expressed in head; intestine; and tail. Orthologous to human POLR2B (RNA polymerase II subunit B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rpb-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (4939567..4944404)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings suggest that SIG-7 plays a central role in both Pol II elongation and co-transcriptional splicing and may provide an important link for their coordination and regulation
Title: A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-222 (e-PCR)
- UniSTS:242069

C26E6.4 (e-PCR)
- UniSTS:309152

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II, core complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase II subunit RPB2

NP_498047.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4939567..4944404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065646.8 → NP_498047.2 DNA-directed RNA polymerase II subunit RPB2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10578

Conserved Domains (1) summary

PRK08565
Location:35 → 1183

PRK08565; DNA-directed RNA polymerase subunit B; Provisional