spe-26 Spermatocyte protein spe-26 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spe-26
Official Full Name: Spermatocyte protein spe-26
Primary source: WormBase:WBGene00004972
Locus tag: CELE_R10H10.2
See related: AllianceGenome:WB:WBGene00004972
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in spermatocyte and in male. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Orthologous to human KLHL10 (kelch like family member 10). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See spe-26 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (10389578..10391927, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R10H10.2 (e-PCR)
- UniSTS:321640

R10H10.3 (e-PCR)
- UniSTS:314792

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Spermatocyte protein spe-26

NP_501919.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10389578..10391927 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069518.5 → NP_501919.1 Spermatocyte protein spe-26 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501919.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10579

Conserved Domains (4) summary

smart00612
Location:341 → 393

Kelch; Kelch domain

smart00875
Location:131 → 223

BACK; BTB And C-terminal Kelch

sd00038
Location:282 → 324

Kelch; KELCH repeat [structural motif]

pfam01344
Location:282 → 325

Kelch_1; Kelch motif