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    npr-24 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187897, updated on 4-Jan-2025

    Summary

    Official Symbol
    npr-24
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00020086
    Locus tag
    CELE_R106.2
    See related
    AllianceGenome:WB:WBGene00020086
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; drug dependence (multiple); drug psychosis; and withdrawal disorder (multiple). Orthologous to several human genes including SSTR2 (somatostatin receptor 2); SSTR4 (somatostatin receptor 4); and SSTR5 (somatostatin receptor 5). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See npr-24 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (17483008..17486835, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-1;Nuclear receptor domain-containing protein Neighboring gene Putative potassium channel regulatory protein sup-10

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables G protein-coupled receptor activity  
    enables peptide binding  
    Component Evidence Code Pubs
    located_in membrane  
    is_active_in neuron projection  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_510833.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      17483008..17486835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078432.7NP_510833.3  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510833.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23033
      Conserved Domains (2) summary
      cd14964
      Location:2546
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:25326
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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