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    • Showing Current items.

    tsp-12 Tetraspanin-12 [ Caenorhabditis elegans ]

    Gene ID: 177890, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tsp-12
    Official Full Name
    Tetraspanin-12
    Primary source
    WormBase:WBGene00006638
    Locus tag
    CELE_T14G10.6
    See related
    AllianceGenome:WB:WBGene00006638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protease binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of egg-laying behavior; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasmic vesicle membrane and plasma membrane. Is expressed in several structures, including M lineage cell; germ line; intestine; pharynx; and vulval precursor cell. Used to study cancer. Orthologous to human TSPAN14 (tetraspanin 14); TSPAN17 (tetraspanin 17); and TSPAN5 (tetraspanin 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tsp-12 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (10149166..10150602, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SH2 domain-containing protein Neighboring gene GPI transamidase component PIG-S Neighboring gene ncRNA Neighboring gene Coatomer subunit gamma;putative coatomer subunit gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells. Dunn CD, et al. Proc Natl Acad Sci U S A, 2010 Mar 30. PMID 20220101, Free PMC Article
    2. Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans. Wang L, et al. PLoS Genet, 2017 Jan. PMID 28068334, Free PMC Article
    3. The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function. Liu Z, et al. PLoS Genet, 2022 Jan. PMID 35089916, Free PMC Article
    4. Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans. Liu Z, et al. Proc Natl Acad Sci U S A, 2020 Feb 11. PMID 31988138, Free PMC Article
    5. Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids. Liu Z, et al. PLoS Genet, 2015 May. PMID 25978409, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function.
      Title: The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function.
    2. TSP-12 and TSP-14 are required for the recycling of DAF-4/BMPRII.
      Title: Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans.
    3. TSP-12 can bind to and promote the cell surface localization of SUP-17. TSP-12 and TSP-14 function redundantly to promote BMP signaling.
      Title: Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nematode male tail tip morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mesodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tetraspanin-12
    NP_501853.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10149166..10150602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069452.5 → NP_501853.1  Tetraspanin-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22495
      Conserved Domains (1) summary
      pfam00335
      Location:38 → 293
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22495.1

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