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    inx-9 Innexin [ Caenorhabditis elegans ]

    Gene ID: 191694, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inx-9
    Official Full Name
    Innexin
    Primary source
    WormBase:WBGene00002131
    Locus tag
    CELE_ZK792.3
    See related
    AllianceGenome:WB:WBGene00002131
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gap junction channel activity. Acts upstream of or within with a positive effect on germ cell proliferation. Located in gap junction. Is expressed in several structures, including gonad; interfacial epithelial cell; nerve ring neurons; pharyngeal cell; and somatic gonad precursor. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inx-9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (11676354..11678497)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cysteine protease atg-4.2 Neighboring gene Innexin-8 Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gap junctional protein INX-14 functions in oocyte precursors to promote C. elegans sperm guidance. Edmonds JW, et al. Dev Biol, 2011 Nov 1. PMID 21889935, Free PMC Article
    2. Gap junctions deliver malonyl-CoA from soma to germline to support embryogenesis in Caenorhabditis elegans. Starich TA, et al. Elife, 2020 Jul 31. PMID 32735213, Free PMC Article
    3. A Limited and Diverse Set of Suppressor Mutations Restore Function to INX-8 Mutant Hemichannels in the Caenorhabditis elegans Somatic Gonad. Starich T, et al. Biomolecules, 2020 Dec 10. PMID 33321846, Free PMC Article
    4. Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche. Gordon KL, et al. Elife, 2020 Jul 21. PMID 32692313, Free PMC Article
    5. Two classes of gap junction channels mediate soma-germline interactions essential for germline proliferation and gametogenesis in Caenorhabditis elegans. Starich TA, et al. Genetics, 2014 Nov. PMID 25195067, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect germ cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Innexin
    NP_502210.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11676354..11678497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069809.3 → NP_502210.2  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502210.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23594
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 359
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version

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