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    fkh-10 Fork-head domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fkh-10
    Official Full Name
    Fork-head domain-containing protein
    Primary source
    WormBase:WBGene00001442
    Locus tag
    CELE_C25A1.2
    See related
    AllianceGenome:WB:WBGene00001442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in gonad; head ganglion; head neurons; and pharyngeal neurons. Orthologous to human FOXL3-OT1 (FOXL3 overlapping transcript 1) and FOXL3 (forkhead box L3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fkh-10 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (10163475..10165132, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene TPX2 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene mRNA cap guanine-N(7) methyltransferase Neighboring gene FAM192A/Fyv6 N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene RRM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components. Tarailo M, et al. Genetics, 2007 Dec. PMID 18073444, Free PMC Article
    2. The forkhead gene family of Caenorhabditis elegans. Hope IA, et al. Gene, 2003 Jan 30. PMID 12568714
    3. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Panowski SH, et al. Nature, 2007 May 31. PMID 17476212
    4. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fork-head domain-containing protein
    NP_492676.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10163475..10165132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060275.7 → NP_492676.2  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492676.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17593
      Conserved Domains (1) summary
      pfam00250
      Location:41 → 125
      Forkhead; Forkhead domain
    Nucleotide Protein
    Heading Accession and Version

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