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    pbo-4 Na(+)/H(+) exchanger protein 7 [ Caenorhabditis elegans ]

    Gene ID: 181285, updated on 9-Dec-2024

    Summary

    Official Symbol
    pbo-4
    Official Full Name
    Na(+)/H(+) exchanger protein 7
    Primary source
    WormBase:WBGene00003943
    Locus tag
    CELE_K09C8.1
    See related
    AllianceGenome:WB:WBGene00003943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Involved in several processes, including defecation; lipid transport involved in lipid storage; and positive regulation of intestinal lipid absorption. Located in basolateral plasma membrane. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See pbo-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (10954134..10958233)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Apple domain-containing protein Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Neuropeptide-Like Protein Neighboring gene Transmembrane protein Neighboring gene Zinc metalloproteinase nas-10

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid transport involved in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of intestinal lipid absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of striated muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cellular pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Na(+)/H(+) exchanger protein 7
    NP_509830.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10954134..10958233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077429.9NP_509830.2  Na(+)/H(+) exchanger protein 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509830.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBK1
      Conserved Domains (1) summary
      pfam00999
      Location:115519
      Na_H_Exchanger; Sodium/hydrogen exchanger family