hum-7 Unconventional myosin-IXa-like [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hum-7
Official Full Name: Unconventional myosin-IXa-like
Primary source: WormBase:WBGene00002040
Locus tag: CELE_F56A6.2
See related: AllianceGenome:WB:WBGene00002040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calmodulin binding activity and plus-end directed microfilament motor activity. Involved in actin-myosin filament sliding. Predicted to be part of myosin complex. Predicted to be active in actin filament. Is expressed in accessory cell; body wall musculature; and pharynx. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to several human genes including MYO9A (myosin IXA). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hum-7 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 30

Sequence:: Chromosome: I; NC_003279.8 (585807..607571, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RHO-1 activity is regulated by SAX-3/ROBO acting on the RhoGAP HUM-7.
Title: The RhoGAP HUM-7/Myo9 integrates signals to modulate RHO-1/RhoA during embryonic morphogenesis in Caenorhabditiselegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F56A6.2 (e-PCR)
- UniSTS:314484

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end directed microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin-myosin filament sliding	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Unconventional myosin-IXa-like

NP_001248879.1

Confirmed by transcript evidence

NP_001248880.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

585807..607571 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001261951.3 → NP_001248880.1 Unconventional myosin-IXa-like [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001248880.1

Status: REVIEWED

UniProtKB/TrEMBL

F0IWT2

Conserved Domains (5) summary

smart00242
Location:163 → 936

MYSc; Myosin. Large ATPases

smart00314
Location:28 → 134

RA; Ras association (RalGDS/AF-6) domain

cd00029
Location:1475 → 1523

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01385
Location:181 → 936

MYSc_Myo9; class IX myosin, motor domain

cl02570
Location:1540 → 1727

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001261950.4 → NP_001248879.1 Unconventional myosin-IXa-like [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001248879.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L082

Conserved Domains (5) summary

smart00242
Location:163 → 936

MYSc; Myosin. Large ATPases

smart00314
Location:28 → 134

RA; Ras association (RalGDS/AF-6) domain

cd00029
Location:1462 → 1510

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01385
Location:181 → 936

MYSc_Myo9; class IX myosin, motor domain

cl02570
Location:1527 → 1714

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...