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    hlh-10 Helix-loop-helix protein 10 [ Caenorhabditis elegans ]

    Gene ID: 191402, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hlh-10
    Official Full Name
    Helix-loop-helix protein 10
    Primary source
    WormBase:WBGene00001954
    Locus tag
    CELE_ZK682.4
    See related
    AllianceGenome:WB:WBGene00001954
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein heterodimerization activity and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in neurons. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human MSC (musculin) and TCF21 (transcription factor 21). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hlh-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (9280512..9282210, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Leucine-rich repeat-containing protein 15-like Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the activated B-cell factor 1 homolog in Caenorhabditis elegans. Nguyen L, et al. Nucleic Acids Res, 2001 Nov 1. PMID 11691930, Free PMC Article
    2. Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors. Gruner M, et al. PLoS Genet, 2016 Aug. PMID 27487365, Free PMC Article
    3. Identification of C. elegans sensory ray genes using whole-genome expression profiling. Portman DS, et al. Dev Biol, 2004 Jun 15. PMID 15183729
    4. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Grove CA, et al. Cell, 2009 Jul 23. PMID 19632181, Free PMC Article
    5. The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron. Etchberger JF, et al. Genes Dev, 2007 Jul 1. PMID 17606643, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Helix-loop-helix protein 10
    NP_505401.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9280512..9282210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073000.4 → NP_505401.2  Helix-loop-helix protein 10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505401.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23579
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23579.2

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