abt-2 ABC transporter domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: abt-2
Official Full Name: ABC transporter domain-containing protein
Primary source: WormBase:WBGene00000020
Locus tag: CELE_F12B6.1
See related: AllianceGenome:WB:WBGene00000020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); autosomal recessive congenital ichthyosis (multiple); hypolipoproteinemia (multiple); retinal degeneration (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including ABCA12 (ATP binding cassette subfamily A member 12). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See abt-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 33

Sequence:: Chromosome: I; NC_003279.8 (2255921..2272866, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F12B6.1 (e-PCR)
- UniSTS:315254

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ABC transporter domain-containing protein

NP_001368466.1

Confirmed by transcript evidence

NP_490949.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

2255921..2272866 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058548.7 → NP_490949.3 ABC transporter domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490949.3

Status: REVIEWED

UniProtKB/TrEMBL

G4SD95, Q1RS86

Conserved Domains (2) summary

TIGR01257
Location:39 → 2117

rim_protein; retinal-specific rim ABC transporter

cd03263
Location:929 → 1134

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
NM_001381367.1 → NP_001368466.1 ABC transporter domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

X5LXB2

Conserved Domains (1) summary

TIGR01257
Location:2 → 2080

rim_protein; retinal-specific rim ABC transporter