mak-2 MAP kinase-activated protein kinase mak-2 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: mak-2
Official Full Name: MAP kinase-activated protein kinase mak-2
Primary source: WormBase:WBGene00007007
Locus tag: CELE_C44C8.6
See related: AllianceGenome:WB:WBGene00007007
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables mitogen-activated protein kinase binding activity. Involved in several processes, including behavioral response to nicotine; positive regulation of 3'-UTR-mediated mRNA stabilization; and regulation of axon extension. Located in cytoplasm; nucleus; and synapse. Is expressed in body wall musculature; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2) and MAPKAPK3 (MAPK activated protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in behavioral response to nicotine	IGI Inferred from Genetic Interaction more info	PubMed
involved_in behavioral response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of 3'-UTR-mediated mRNA stabilization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of presynapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

NP_001379801.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain