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    sir-2.3 NAD-dependent protein deacylase sir-2.3 [ Caenorhabditis elegans ]

    Gene ID: 185876, updated on 27-Dec-2024

    Summary

    Official Symbol
    sir-2.3
    Official Full Name
    NAD-dependent protein deacylase sir-2.3
    Primary source
    WormBase:WBGene00004802
    Locus tag
    CELE_F46G10.3
    See related
    AllianceGenome:WB:WBGene00004802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable NAD+ binding activity and histone deacetylase activity, NAD-dependent. Located in mitochondrion. Is expressed in body wall musculature; head; pharynx; and somatic gonad. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See sir-2.3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (13332014..13333846)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SEFIR domain-containing protein Neighboring gene NAD-dependent protein deacylase sir-2.2 Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene SSD domain-containing protein

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD+ binding  
    enables NAD+ binding  
    enables NAD-dependent protein lysine deacetylase activity  
    enables histone deacetylase activity, NAD-dependent  
    enables metal ion binding  
    enables protein lysine deacetylase activity  
    enables transferase activity  
    enables zinc ion binding  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix  
    located_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    located_in mitochondrion  

    General protein information

    Preferred Names
    NAD-dependent protein deacylase sir-2.3
    NP_510220.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13332014..13333846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077819.4 → NP_510220.1  NAD-dependent protein deacylase sir-2.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510220.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20481
      Conserved Domains (1) summary
      cd01409
      Location:20 → 284
      SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
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