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    mcm-3AP PCI domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mcm-3AP
    Official Full Name
    PCI domain-containing protein
    Primary source
    WormBase:WBGene00017642
    Locus tag
    CELE_F20D12.2
    See related
    AllianceGenome:WB:WBGene00017642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mRNA export from nucleus. Predicted to be part of transcription export complex 2. Predicted to be active in cytoplasm and nucleus. Is expressed in head; intestine; nervous system; and tail. Orthologous to human MCM3AP (minichromosome maintenance complex component 3 associated protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mcm-3AP in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (7948672..7953548)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Centromere/kinetochore protein zw10 homolog Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Homeobox protein ceh-19 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Piwi domain-containing protein Neighboring gene Tyrosine-protein phosphatase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
    2. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription export complex 2 IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PCI domain-containing protein
    NP_501328.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7948672..7953548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068927.8 → NP_501328.1  PCI domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19643
      Conserved Domains (2) summary
      pfam03399
      Location:291 → 582
      SAC3_GANP; SAC3/GANP family
      cl19107
      Location:687 → 788
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein
    Heading Accession and Version

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